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KMID : 1033620180450040189
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Clinical and Experimental Reproductive Medicine
2018 Volume.45 No. 4 p.189 ~ p.194
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Developmental competence of in vitro-matured human oocytes obtained from pregnant and non-pregnant women
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Pongsuthirak Pallop
Vutyavanich Teraporn
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Abstract
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Objective: The aim of this study was to compare the rate of maturation, fertilization, and embryo development of in vitro-matured human oocytes derived from pregnant and non-pregnant women.
Methods: Immature oocytes were obtained by needle aspiration from 49 pregnant women (group 1) who underwent a cesarean section at term and 77 non-pregnant women (group 2) who underwent a gynecological operation during the same period (8 months). Healthy immature oocytes (530 in group 1 and 539 in group 2) were cultured and assessed for maturation 36 hours later. Mature oocytes were inseminated by intracytoplasmic sperm injection and cultured up to 144 hours.
Results: The percentage of degenerated oocytes was significantly higher (12.1% vs. 6.3%; p<0.001) in group 1 than in group 2. There was no significant difference in the maturation rate (66.8% vs. 68.1%; p=0.698), fertilization rate (66.7% vs. 67.6%; p=0.857), or the rate of formation of good-quality blastocysts (46.2% vs. 47.2%; p=0.898) in oocytes obtained from pregnant and non-pregnant women.
Conclusion: The developmental competence of immature oocytes did not differ between pregnant and non-pregnant women.
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KEYWORD
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Competence, Oocyte in vitro maturation, Pregnant women
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